Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
extracellular | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96PE3 | - |
- |
Mus musculus | Q9EPW0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | airway epithelial cell | Homo sapiens | - |
epithelium | airway epithelial cell | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
INPP4A | - |
Homo sapiens |
INPP4A | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | INPP4a is secreted by airway epithelial cells and extracellular INPP4A critically inhibits airway inflammation and remodeling. INPP4A is present in blood and broncho-alveolar lavage fluid and is reduced in asthma patients. Cultured airway epithelial cells secrete enzymatically active INPP4A in extracellular vesicles and in a free form. Extracellular vesicles-mediated INPP4A is transferred from epithelial cells to fibroblasts. Inhibition of this transfer increases fibroblast proliferation | Homo sapiens |
physiological function | INPP4a is secreted by airway epithelial cells and extracellular INPP4A critically inhibits airway inflammation and remodeling. INPP4A is present in blood and broncho-alveolar lavage fluid and is reduced in mice with allergic airway inflammation. In mice with allergic airway inflammation as well as naive mice, antibody-mediated neutralization of extracellular INPP4A potentiates PI3K/Akt signaling and induces airway hyperresponsiveness, with prominent airway remodeling, sub-epithelial fibroblast proliferation and collagen deposition | Mus musculus |